Microchimerism is a bidirectional exchange of fetal and maternal cells during pregnancy (Figure 1). Pregnancy is the most common and natural cause of chimerism, and bi-directional trafficking of hematopoietic cells occurs through the placenta. Therefore, we are all born as microchimera [1,2]. Although there are many unanswered questions it is thought that chimerism has an important role in human health. For many years, the clinical effects of maternal microchimeric cells (MMcCs) in organ repair and cancer therapy have just begun to be understood. While the mission of chimerism is straight forward, the subject is profound. Chimerism carries the potential for disease as well as for health benefits. Recent studies have shown that maternal stress and infections in pregnancy affect fetal neuro development and increased the risk of neurological or psychiatric disorders in the future life of the fetus. This article describes the role of Mc in the etiology of psychotic disorders.
Miranda PD, Goulmy E. We are all born as microchimera. Chimerism. 2013; 4: 18-19. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23262442
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Zeng XX, Tan KH, Yeo A, Sasajala P, Tan X, et al. Pregnancy-associated progenitor cells differentiate and mature into neurons in the maternal brain. Stem Cells Dev. 2010; 19: 1-12. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20707697
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Estes ML, McAllister AK. Immune mediators in the brain and peripheral tissues in autism spectrum disorder. Nat Rev Neurosci. 2015; 16: 469-486. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26189694
Patterson PH. Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav Brain Res. 2009; 204: 313-321. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19136031
Işıkay CT, Özsan H. Şizofrenide viral ve otoimmün etyoloji; literatürün gözden geçirilmesi. Ankara Üniversitesi, Tıp Fakültesi Mecmuası. 1998; 51: 101-106.
Howes OD, McCutcheon R. Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization. Transl Psychiatry. 2017; 7: e1024. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28170004
Kirkpatrick B, Miller BJ. Inflammation and schizophrenia. Schzophr Bull. 2013; 39: 1174-1179. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24072812
Khandaker GM, Cousins L, Deakin J, Lennox BR, Yolken R, et al. Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment. Lancet Psychiatry. 2015; 2: 197-199. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26359903
Miyaoka T, Wake R, Hashioka S, Hayashida M, Oh-Nishi A, et al. Remission of Psychosis in Treatment-Resistant Schizophrenia following Bone Marrow Transplantation: A Case Report. Front Psychiatry. 2017; 8: 174. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28983259
Aydın MŞ, Yiğit EN, Vatandaşlar E, Erdoğan E, Öztürk G. Transfer and Integration of Breast Milk Stem Cells to the Brain of Suckling Pups. Sci Rep. 2018; 8: 14289.
Kacsoh BZ, Bozler J, Bosco G. Drosophila species learn dialects through communal living. Plos Genetics. 2018; 14: e1007430. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30024883
Christian MA, Samms-Vaughan M, Lee M, Bressler J, Hessabi M, et al. Maternal exposures associated with autism spectrum disorder in jamaican children. JAutism Dev Disord. 2018; 48: 2766-2778. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29549549
Glynn LM, Howland MA, Sandman CA, Davis EP, Phelan M, et al. Prenatal maternal mood patterns predict child temperament and adolescent mental health. JAffect Disord. 2018; 228: 83-90. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29241049
Vizzini L, Popovic M, Zugna D, Vitiello B, Trevisan M, et al. Maternal anxiety, depression and sleep disorders before and during pregnancy, and preschool ADHD symptoms in the NINFEA birth cohort study. Epidemiol Psychiatric Sci. 2018; 1-11. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29665879
Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, et al. Early life programming and neurodevelopmental disorders. Biol Psychiatry. 2010; 68: 314-319. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20674602
Fisher J, Cabral de Mello M, Patel V, Rahman A, Tran T, et al. Prevalence and determinants of common perinatal mental disorders in women in low- and lower-middle-income countries: a systematic review. Bull World Health Organ. 2012; 90: 139G-149G. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22423165
Walder DJ, Laplante DP, Sousa-Pires A, Veru F, Brunet A, et al. Prenatal maternal stress predicts autism traits in 6½ yearold children: Project Ice Storm. Psychiatry Res. 2014;219: 353-360. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24907222
Betts KS, Williams GM, Najman JM, Alati R. The relationship between maternal depressive, anxious, and stress symptoms during pregnancy and adult offspring behavioral and emotional problems. Depress Anxiety. 2015; 32: 82-90. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24788841
Kingsbury M, Weeks M, MacKinnon N, Evans J, Mahedy L, et al. Stressful life events during pregnancy and offspring depression: evidence from a prospective cohort study. J Am Acad Child Adolesc Psychiatry. 2016; 55: 709-716e2. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27453085
St-Hilaire A, Steiger H, Liu A, Laplante DP, Thaler L, et al. A prospective study of effects of prenatal maternal stress on later eatingdisorder manifestations in affected offspring: preliminary indications based on the Project Ice Storm cohort. Int J Eat Disord. 2015; 48: 512-516. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25808647
Zhu P, Hao JH, Tao RX, Huang K, Jiang XM, et al. Sex-specific and timedependent effects of prenatal stress on the early behavioral symptoms of ADHD: a longitudinal study in China. Eur Child Adolesc Psychiatry. 2015; 24: 1139-1147. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25791080
Pickles A, Sharp H, Hellier J, Hill J. Prenatal anxiety, maternal stroking in infancy, and symptoms of emotional and behavioral disorders at 3.5 years. Eur Child Adolesc Psychiatry. 2017; 26: 325-334. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27464490
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Demirhan O, Ozturk N, Aydin N, Yildizdas HY, Demirbek B, et al. Effect of fetal microchimeric cells on the development of postnatal depression. Med Clin Arch. 2019; 3: 1-6.
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We appreciate your approach to scholars and will encourage you to collaborate with your organization, which includes interesting and different medical journals.
With the best wishes of success, creativity and joy in life, prosperity in the medical field.
Ivano- Frankivsk National Medical University, Ukraine
Nataliya Kitsera
Thank you very much for your support and encouragement. I am truly impressed by your tolerance and support.
Thank you very much
Diaverum: PADC, Jeddah, Saudi Arabia
Nasrulla Abutaleb
You are such a nice person. Your journal co-operation is very appreciable and motivational.
Department of Biotechnology, Uttaranchal college of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India
Archna Dhasmana
“Mobile apps and wearable technology are becoming ubiquitous in our environment. Their integration with healthcare delivery is just beginning to take shape. The early results are promising and the possibilities great."
BS, PharmD., MBA, CPHIMS, FHIMSS, Adjunct Professor, Global Healthcare Management, MCPHS University, Chief Strategy Offi cer, MedicaSoft, Senior Advisor, National Health IT (NHIT) Collaborative for Underserved, New York HIMSS, National Liaison, Health 2.0 Boston, Past Chair, Chair Innovation, USA
Helen Figge
“The choice to submit the forensic case study to the Journal of Addiction Therapy and Research was dictated by the match between the content and the potential readership. The publication process proved to be expedient and we were provided with constructive feedback from reviewers. The final article layout is attractive and conforms to standards. All-in-all, it has been a rewarding process.”
Ph.D, Boston University Department of Communication Sciences and Disorders and Knowledge Research Institute, Inc., 2131 Reflection Bay Drive, Arlington, Texas 76013, USA
Elisabeth H. Wiig
The service is nice and the time of processing the application is fast.
Department of Neurosurgery, Queen Elizabeth Hospital, Hong Kong
Long Ching
Your service is very good and fast reply, Also your service understand our situation and support us to publication our articles.
Palestine College of Nursing, Khan Younis, Gaza Strip, Palestine
Ayman M Abu Mustafa
“It was a delightful experience publishing my manuscript with the Clinical Journal of Obstetrics and Gynecology. They offered me lots of opportunities I never had from most publishing houses and their prompt services are greatly appreciated.”
Department of Agricultural Economics, Agribusiness and Extension, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
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